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OTUD7B antibody

CAT: 0710-FNab06043Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06043Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.
Synonyms
OTU domain-containing protein 7B|Cellular zinc finger anti-NF-kappa-B protein (Cezanne) |Zinc finger A20 domain-containing protein 1|Zinc finger protein Cezanne|OTUD7B|ZA20D1
Gene ID
56957
UniProt
Q6GQQ9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
OTU domain containing 7B
Target
OTUD7B
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
100 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

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