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ORAI1 antibody

CAT: 0710-FNab06001Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06001Size:100 µg
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Background
Ca (2+) release-activated Ca (2+) (CRAC) channel subunit which mediates Ca (2+) influx following depletion of intracellular Ca (2+) stores and channel activation by the Ca (2+) sensor, STIM1. CRAC channels are the main pathway for Ca (2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901) .
Synonyms
Calcium release-activated calcium channel protein 1|Protein orai-1|Transmembrane protein 142A|ORAI1|CRACM1|TMEM142A
Gene ID
84876
UniProt
Q96D31
Host
Rabbit
Reactivity
Human, Mouse, Rat, Zebrafish
Immunogen
ORAI calcium release-activated calcium modulator 1
Target
ORAI1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF
Field of Research
Immunology, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
45 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF

UniProtKB · Q96D31

Calcium release-activated calcium channel protein 1

ORAI1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96D31
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ORAI1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q3MHV3, Q6DHX2, Q96BP7, Q96K71
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityCalcium transportImmunityIon transportTransport

Coding sequence diversity

Alternative initiation

Ligand

Calcium

Molecular function

Calcium channelCalmodulin-bindingIon channel

Cellular component

Cell membraneMembrane

Disease

Disease variant

PTM

GlycoproteinPhosphoproteinUbl conjugation

Domain

TransmembraneTransmembrane helix

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