OPTN antibody

CAT: 0710-FNab06000Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab06000Size:100 µg
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Background
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD) . Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR) ; regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.
Synonyms
Optineurin|E3-14.7K-interacting protein (FIP-2) |Huntingtin yeast partner L|Huntingtin-interacting protein 7 (HIP-7) |Huntingtin-interacting protein L|NEMO-related protein|Optic neuropathy-inducing protein|Transcription factor IIIA-interacting protein (TFIIIA-IntP) |OPTN|FIP2|GLC1E|HIP7|HYPL|NRP
Gene ID
10133
UniProt
Q96CV9
Host
Mouse
Reactivity
Human
Immunogen
Optineurin
Target
OPTN
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IHC, IF
Field of Research
Neuroscience, Immunology, Signal Transduction
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
66 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
5F4
Tested Applications
ELISA, WB, IHC, IF

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