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OGDH antibody

CAT: 0710-FNab05976Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05976Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO (2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms
2-oxoglutarate dehydrogenase complex component E1 (E1o, OGDC-E1, OGDH-E1) |2-oxoglutarate dehydrogenase, mitochondrial|Alpha-ketoglutarate dehydrogenase (Alpha-KGDH-E1) |Thiamine diphosphate (ThDP) -dependent 2-oxoglutarate dehydrogenase|OGDH
Gene ID
4967
UniProt
Q02218
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Target
OGDH
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
116 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

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