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NUMBL antibody

CAT: 0710-FNab05918Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05918Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
Synonyms
Numb-like protein|Numb-related protein (Numb-R) |NUMBL
Gene ID
9253
UniProt
Q9Y6R0
Host
Mouse
Reactivity
Human
Immunogen
Numb homolog (Drosophila) -like
Target
NUMBL
Clonality
Monoclonal
Isotype
IgG2a
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Developmental biology
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
70 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
8E0
Tested Applications
ELISA, WB, IHC

UniProtKB · Q9Y6R0

Numb-like protein

NUMBL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y6R0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NUMBL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q7Z4J9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cytoplasm

Molecular function

Developmental protein

Biological process

NeurogenesisUbl conjugation pathway

PTM

Phosphoprotein

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