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NR5A1 antibody

CAT: 0710-FNab05847Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05847Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine (By similarity) . Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI (3,4) P2 and PI (3,4,5) P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Synonyms
Steroidogenic factor 1 (SF-1, STF-1, hSF-1) |Adrenal 4-binding protein|Fushi tarazu factor homolog 1|Nuclear receptor subfamily 5 group A member 1|Steroid hormone receptor Ad4BP|NR5A1|AD4BP|FTZF1|SF1
Gene ID
2516
UniProt
Q13285
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Nuclear receptor subfamily 5, group A, member 1
Target
NR5A1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Immunology, Signal Transduction, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:200-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
53 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

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