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NR2C2 antibody

CAT: 0710-FNab05841Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05841Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity) . Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
Synonyms
Nuclear receptor subfamily 2 group C member 2|Orphan nuclear receptor TAK1|Orphan nuclear receptor TR4|Testicular receptor 4|NR2C2|TAK1|TR4
Gene ID
7182
UniProt
P49116
Host
Rabbit
Reactivity
Human
Immunogen
Nuclear receptor subfamily 2, group C, member 2
Target
NR2C2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Signal Transduction, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
70 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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