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NOTCH3 antibody

CAT: 0710-FNab05800Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05800Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) .
Synonyms
Neurogenic locus notch homolog protein 3 (Notch 3) |Notch 3 extracellular truncation|Notch 3 intracellular domain|NOTCH3
Gene ID
4854
UniProt
Q9UM47
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Notch homolog 3
Target
NOTCH3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
250-260 kDa, 100 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

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