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NMRAL1 antibody

CAT: 0710-FNab05769Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05769Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP (+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP (+) . Binding to NADPH is necessary to form a stable dimer.
Synonyms
NmrA-like family domain-containing protein 1|NMRAL1|HSCARG
Gene ID
57407
UniProt
Q9HBL8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
NmrA-like family domain containing 1
Target
NMRAL1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
33 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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