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NME1 antibody

CAT: 0710-FNab05762Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05762Size:100 µg
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Background
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
Synonyms
Nucleoside diphosphate kinase A (NDK A, NDP kinase A) |Granzyme A-activated DNase (GAAD) |Metastasis inhibition factor nm23|NM23-H1|Tumor metastatic process-associated protein|NME1|NDPKA|NM23
Gene ID
4830
UniProt
P15531
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Non-metastatic cells 1, protein (NM23A) expressed in
Target
NME1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Cancer, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
21 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

UniProtKB · P15531

Nucleoside diphosphate kinase A

NDKA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P15531
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NME1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
NDP kinase A, NDPK A
EC number
2.7.4.6
Processing
—
Secondary accessions
Q6FGK3, Q86XQ2, Q9UDJ6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationDisulfide bondGlutathionylationIsopeptide bondOxidationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Cellular component

Cell membraneCytoplasmMembraneNucleus

Biological process

DifferentiationEndocytosisNeurogenesisNucleotide metabolism

Molecular function

HydrolaseKinaseTransferase

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