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NFKBIZ antibody

CAT: 0710-FNab05709Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05709Size:100 µg
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Background
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity) .
Synonyms
NF-kappa-B inhibitor zeta|I-kappa-B-zeta (IkB-zeta, IkappaBzeta) |IL-1 inducible nuclear ankyrin-repeat protein (INAP) |Molecule possessing ankyrin repeats induced by lipopolysaccharide (MAIL) |NFKBIZ|IKBZ|INAP|MAIL
Gene ID
64332
UniProt
Q9BYH8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Target
NFKBIZ
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB
Field of Research
Epigenetics, Immunology, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
64 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB

UniProtKB · Q9BYH8

NF-kappa-B inhibitor zeta

IKBZ_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9BYH8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NFKBIZ
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B3KNR2, D3DN54, Q8IUL4, Q8NAZ8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorRepressor

Coding sequence diversity

Alternative splicing

Domain

ANK repeatRepeat

Cellular component

Nucleus

Biological process

TranscriptionTranscription regulation

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