CDH2 antibody

• Background :

  Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) .

• Synonyms :

  Cadherin-2|CDw325|Neural cadherin (N-cadherin) |CDH2|CDHN|NCAD

• Gene ID :

  1000

• UniProt :

  P19022

• Host :

  Mouse

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Cadherin 2, type 1, N-cadherin (neuronal)

• Target :

  CDH2

• Clonality :

  Monoclonal

• Isotype :

  IgG2a

• Applications :

  ELISA, IHC, WB

• Field of Research :

  Signal Transduction, Cardiovascular, Immunology, Neuroscience, Stem Cells

• Purification :

  Protein A+G purification

• Dilution :

  WB: 1:1000-1:10000; IHC: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  130 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID :

  1G1

• Tested Applications :

  ELISA, IHC, WB