NAT10 antibody

• Background:

  RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs (PubMed:25653167) . Catalyzes the formation of N (4) -acetylcytidine (ac4C) at positions 1337 and 1842 in 18S rRNA (By similarity) . Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25653167) . Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity) . Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167) . Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division (PubMed:14592445, PubMed:17631499, PubMed:18082603, PubMed:19303003) .

• Synonyms:

  RNA cytidine acetyltransferase|18S rRNA cytosine acetyltransferase|N-acetyltransferase 10|N-acetyltransferase-like protein (hALP) |NAT10|ALP|KIAA1709

• Gene ID:

  55226

• UniProt:

  Q9H0A0

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  N-acetyltransferase 10 (GCN5-related)

• Target:

  NAT10

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IF, IP

• Field of Research:

  Cell Division and Proliferation, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  116 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IF, IP