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NANOS3 antibody

CAT: 0710-FNab05542Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05542Size:100 µg
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Background
Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and-independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.
Synonyms
Nanos homolog 3 (NOS-3) |NANOS3|NOS3
Gene ID
342977
UniProt
P60323
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Nanos homolog 3 (Drosophila)
Target
NANOS3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Cell Division and Proliferation, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
26-30 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · P60323

Nanos homolog 3

NANO3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P60323
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NANOS3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
NOS-3
EC number
—
Processing
—
Secondary accessions
Q495E5
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Molecular function

Developmental proteinRNA-binding

Biological process

DifferentiationOogenesisSpermatogenesisTranslation regulation

Ligand

Metal-bindingZinc

Technical term

Proteomics identificationReference proteome

Domain

Zinc-finger

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