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MTF2 antibody

CAT: 0710-FNab05397Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05397Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity) .
Synonyms
Metal-response element-binding transcription factor 2|Metal regulatory transcription factor 2|Metal-response element DNA-binding protein M96|Polycomb-like protein 2 (hPCl2) |MTF2|PCL2
Gene ID
22823
UniProt
Q9Y483
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Metal response element binding transcription factor 2
Target
MTF2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, IP
Field of Research
Stem Cells, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:50-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60-61 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF, IP

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