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MSL1 antibody

CAT: 0710-FNab05379Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05379Size:100 µg
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Background
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) . This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.
Synonyms
Male-specific lethal 1 homolog (MSL-1) |Male-specific lethal 1-like 1 (MSL1-like 1) |Male-specific lethal-1 homolog 1|MSL1|MSL1L1
Gene ID
339287
UniProt
Q68DK7
Host
Rabbit
Reactivity
Human
Immunogen
Male-specific lethal 1 homolog (Drosophila)
Target
MSL1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
67 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
Immunogen Sequence
473-614aa

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