MITF antibody

• Background:

  Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR) . Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) . Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

• Synonyms:

  Microphthalmia-associated transcription factor|Class E basic helix-loop-helix protein 32 (bHLHe32) |MITF|BHLHE32

• Gene ID:

  4286

• UniProt:

  O75030

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Microphthalmia-associated transcription factor

• Target:

  MITF

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, FC, IP

• Field of Research:

  Epigenetics, Metabolism, Immunology, Developmental biology, Neuroscience

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000; IP: 1:500-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  60-65 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, FC, IP