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MIA3 antibody

CAT: 0710-FNab05174Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05174Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255) .
Synonyms
Transport and Golgi organization protein 1 homolog (TANGO1) |C219-reactive peptide|D320|Melanoma inhibitory activity protein 3|MIA3|KIAA0268|TANGO
Gene ID
375056
UniProt
Q5JRA6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Melanoma inhibitory activity family, member 3
Target
MIA3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IP, WB
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
250-300 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IP, WB

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