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MFN2 antibody

CAT: 0710-FNab05151Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05151Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) . Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.
Synonyms
Mitofusin-2|Transmembrane GTPase MFN2|MFN2|CPRP1|KIAA0214
Gene ID
9927
UniProt
O95140
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Mitofusin 2
Target
MFN2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP, IHC
Field of Research
Neuroscience, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
IP: 1:200-1:1000; WB: 1:200-1:1000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
86 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP, IHC

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