MDC1 antibody
CAT:
710-FNab05072
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
MDC1 antibody
- Background: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
- Synonyms: Mediator of DNA damage checkpoint protein 1|Nuclear factor with BRCT domains 1|MDC1|KIAA0170|NFBD1
- CAS Number: 9007-83-4
- Gene ID: 9656
- UniProt: Q14676
- Host: Rabbit
- Reactivity: Human
- Immunogen: mediator of DNA damage checkpoint 1
- Target: MDC1
- Clonality: Polyclonal
- Isotype: IgG
- Applications: ELISA, IHC, WB
- Field of Research: Epigenetics, Metabolism
- Purification: Immunogen affinity purified
- Dilution: WB: 1:500 - 1:2000; IHC: 1:100 - 1:200
- Purity: ≥95% as determined by SDS-PAGE
- Form: Liquid
- Molecular Weight: 270 kDa
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)