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MDC1 antibody

CAT: 0710-FNab05072Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05072Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Synonyms
Mediator of DNA damage checkpoint protein 1|Nuclear factor with BRCT domains 1|MDC1|KIAA0170|NFBD1
Gene ID
9656
UniProt
Q14676
Host
Rabbit
Reactivity
Human
Immunogen
Mediator of DNA damage checkpoint 1
Target
MDC1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:100 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
270 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB

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