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MASP1 antibody

CAT: 0710-FNab05021Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05021Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.
Synonyms
Mannan-binding lectin serine protease 1|Complement factor MASP-3|Complement-activating component of Ra-reactive factor|Mannose-binding lectin-associated serine protease 1 (MASP-1) |Mannose-binding protein-associated serine protease|Ra-reactive factor serine protease p100 (RaRF) |Serine protease 5|Mannan-binding lectin serine protease 1 heavy chain|Mannan-binding lectin serine protease 1 light chain|MASP1|CRARF|CRARF1|PRSS5
Gene ID
5648
UniProt
P48740
Host
Rabbit
Reactivity
Human
Immunogen
Mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
Target
MASP1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
40-70 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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