MASP1 antibody

• Background:

  Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.

• Synonyms:

  Mannan-binding lectin serine protease 1|Complement factor MASP-3|Complement-activating component of Ra-reactive factor|Mannose-binding lectin-associated serine protease 1 (MASP-1) |Mannose-binding protein-associated serine protease|Ra-reactive factor serine protease p100 (RaRF) |Serine protease 5|Mannan-binding lectin serine protease 1 heavy chain|Mannan-binding lectin serine protease 1 light chain|MASP1|CRARF|CRARF1|PRSS5

• Gene ID:

  5648

• UniProt:

  P48740

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)

• Target:

  MASP1

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  40-70 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB