MAGOH antibody

CAT: 0710-FNab04954Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0710-FNab04954Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD) . The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes) ; specifically inhibits formation of proapoptotic isoforms such as Bcl-X (S) ; the function is different from the established EJC assembly.

Synonyms

Protein mago nashi homolog|MAGOH|MAGOHA

Gene ID

4116

UniProt

P61326

Host

Rabbit

Reactivity

Human

Immunogen

Mago-nashi homolog, proliferation-associated (Drosophila)

Target

MAGOH

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, IHC, IP, WB

Field of Research

Neuroscience, Stem Cells, Metabolism, Developmental biology

Purification

Immunogen affinity purified

Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

17 kDa

Shipping Conditions

4°C with ice bag

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, IHC, IP, WB

UniProtKB · P61326

Protein mago nashi homolog

MGN_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P61326
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: MAGOH
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: B1ARP8, B2R5A2, O35169, P50606, Q5SW69

Protein keywords

Technical term

3D-structureReference proteome

PTM

Acetylation

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleusSpliceosome

Biological process

mRNA processingmRNA splicingmRNA transportNonsense-mediated mRNA decayTranslation regulationTransport

Molecular function

RNA-binding

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Alternative Products

Catalog	Name
GTR18023359	Magoh Antibody