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MAFB antibody

CAT: 0710-FNab04930Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04930Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity) . Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
Synonyms
Transcription factor MafB (Maf-B) |V-maf musculoaponeurotic fibrosarcoma oncogene homolog B|MAFB|KRML
Gene ID
9935
UniProt
Q9Y5Q3
Host
Rabbit
Reactivity
Human, Rat
Immunogen
V-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
Target
MAFB
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
45 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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