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MACF1 antibody

CAT: 0710-FNab04921Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04921Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells (By similarity) .
Synonyms
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5|620 kDa actin-binding protein (ABP620) |Actin cross-linking family protein 7|Macrophin-1|Trabeculin-alpha|MACF1|ABP620|ACF7|KIAA0465|KIAA0754|KIAA1251
Gene ID
23499
UniProt
Q9UPN3
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Microtubule-actin crosslinking factor 1
Target
MACF1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
83 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, IF

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