LRSAM1 antibody

• Background:

  E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501) . Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322) . Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098) .

• Synonyms:

  E3 ubiquitin-protein ligase LRSAM1|Leucine-rich repeat and sterile alpha motif-containing protein 1|RING-type E3 ubiquitin transferase LRSAM1|Tsg101-associated ligase (hTAL) |LRSAM1|TAL

• Gene ID:

  90678

• UniProt:

  Q6UWE0

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Leucine rich repeat and sterile alpha motif containing 1

• Target:

  LRSAM1

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC, IF

• Field of Research:

  Epigenetics, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  84 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC, IF