LRP5 antibody

• Background :

  This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants.

• Synonyms :

  Low-density lipoprotein receptor-related protein 5 (LRP-5) |Low-density lipoprotein receptor-related protein 7 (LRP-7) |LRP5|LR3|LRP7

• Gene ID :

  4041

• UniProt :

  O75197

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Low density lipoprotein receptor-related protein 5

• Target :

  LRP5

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IHC

• Field of Research :

  Cardiovascular, Metabolism, Developmental biology, Signal Transduction

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  180 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IHC

• Immunogen Sequence :

  1408-1615aa