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LCAT antibody

CAT: 0710-FNab04722Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04722Size:100 µg
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Background
Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:10329423, PubMed:19065001, PubMed:26195816) . The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107) . Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE-and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:10722751) .
Synonyms
Phosphatidylcholine-sterol acyltransferase|1-alkyl-2-acetylglycerophosphocholine esterase|Lecithin-cholesterol acyltransferase|Phospholipid-cholesterol acyltransferase|Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) |LCAT
Gene ID
3931
UniProt
P04180
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Lecithin-cholesterol acyltransferase
Target
LCAT
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
55 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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