KISS1 antibody

KISS1 antibody

• Background: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
• Synonyms: Metastasis-suppressor KiSS-1|Kisspeptin-1|Metastin Alternative names: Kisspeptin-54|Kisspeptin-14|Kisspeptin-13|Kisspeptin-10|KISS1
• Gene ID: 3814
• UniProt: Q15726
• Host: Rabbit
• Reactivity: Human, Mouse
• Immunogen: KiSS-1 metastasis-suppressor
• Target: KISS1
• Clonality: Polyclonal
• Isotype: IgG
• Applications: ELISA, WB, IHC, IF
• Field of Research: Neuroscience, Signal Transduction
• Purification: Immunogen affinity purified
• Dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
• Purity: ≥95% as determined by SDS-PAGE
• Form: Liquid
• Molecular Weight: 16-20 kDa
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)