Tebufenozide

• Description:

  Tebufenozide is a nonsteroidal ecdysone agonist used to control pest. Tebufenozide has cytotoxic and induces apoptosis in HeLa and insect Tn5B1-4 cells[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H411

• Target:

  Apoptosis; Insecticide; MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Others

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tebufenozide.html

• Concentration:

  10mM

• Purity:

  99.28

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(N(C(C)(C)C)NC(C1=CC=C(CC)C=C1)=O)C2=CC(C)=CC(C)=C2

• Molecular Formula:

  C22H28N2O2

• Molecular Weight:

  352.47

• Precautions:

  H411

• References & Citations:

  [1]Muhammad Fiaz, et al. Toxicological and Morphological Effects of Tebufenozide on Anticarsia Gemmatalis (Lepidoptera: Noctuidae) Larvae. Chemosphere. 2018 Dec;212:337-345.|[2]Xiaoqin Yu, et al. Cytotoxic Effects of Tebufenozide in Vitro Bioassays. Ecotoxicol Environ Saf. 2016 Jul;129:180-8.|[3]Xu W, et al. Tebufenozide induces G1/S cell cycle arrest and apoptosis in human cells. Environ Toxicol Pharmacol. 2017 Jan;49:89-96.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  112410-23-8