KHDRBS3 antibody

RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly (A) . RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068) . Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763) . In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity) . Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068) . Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity) . May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity) . Can bind FABP9 mRNA (By similarity) . May play a role as a negative regulator of cell growth. Inhibits cell proliferation. (Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression.

KH domain-containing, RNA-binding, signal transduction-associated protein 3|RNA-binding protein T-Star|Sam68-like mammalian protein 2 (SLM-2) |Sam68-like phosphotyrosine protein|KHDRBS3|SALP|SLM2

10656

O75525

Human, Mouse, Rat

KH domain containing, RNA binding, signal transduction associated 3

KHDRBS3

ELISA, WB, IHC

Metabolism, Developmental biology

Immunogen affinity purified

WB: 1:500-1:2000; IHC: 1:20-1:200

≥95% as determined by SDS-PAGE

Liquid

55 kDa

4°C with ice bag

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)