KEAP1 antibody

• Background:

  Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

• Synonyms:

  Kelch-like ECH-associated protein 1|Cytosolic inhibitor of Nrf2 (INrf2) |Kelch-like protein 19|KEAP1|INRF2|KIAA0132|KLHL19

• Gene ID:

  9817

• UniProt:

  Q14145

• Host:

  Mouse

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Kelch-like ECH-associated protein 1

• Target:

  KEAP1

• Clonality:

  Monoclonal

• Isotype:

  IgG2a

• Applications:

  ELISA, IHC, WB, IF

• Field of Research:

  Cancer, Metabolism

• Purification:

  Protein A+G purification

• Dilution:

  WB: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  55-70 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID:

  9E2

• Tested Applications:

  ELISA, IHC, WB, IF

• Immunogen Sequence:

  350-624aa