KEAP1 antibody

CAT: 0710-FNab04517Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab04517Size:100 µg
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Background
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Synonyms
Kelch-like ECH-associated protein 1|Cytosolic inhibitor of Nrf2 (INrf2) |Kelch-like protein 19|KEAP1|INRF2|KIAA0132|KLHL19
Gene ID
9817
UniProt
Q14145
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Kelch-like ECH-associated protein 1
Target
KEAP1
Clonality
Monoclonal
Isotype
IgG2a
Applications
ELISA, IHC, WB, IF
Field of Research
Cancer, Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
55-70 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
9E2
Tested Applications
ELISA, IHC, WB, IF
Immunogen Sequence
350-624aa

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