KDM2A antibody

• Background:

  Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono-and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.

• Synonyms:

  Lysine-specific demethylase 2A|CXXC-type zinc finger protein 8|F-box and leucine-rich repeat protein 11|F-box protein FBL7|F-box protein Lilina|F-box/LRR-repeat protein 11|JmjC domain-containing histone demethylation protein 1A|[Histone-H3]-lysine-36 demethylase 1A|KDM2A|CXXC8|FBL11|FBL7|FBXL11|JHDM1A|KIAA1004

• Gene ID:

  22992

• UniProt:

  Q9Y2K7

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Lysine (K) -specific demethylase 2A

• Target:

  KDM2A

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Epigenetics, Cancer, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  80-132 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC

• Immunogen Sequence:

  369-649aa