KDM2A antibody

CAT: 0710-FNab04509Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab04509Size:100 µg
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Background
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono-and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.
Synonyms
Lysine-specific demethylase 2A|CXXC-type zinc finger protein 8|F-box and leucine-rich repeat protein 11|F-box protein FBL7|F-box protein Lilina|F-box/LRR-repeat protein 11|JmjC domain-containing histone demethylation protein 1A|[Histone-H3]-lysine-36 demethylase 1A|KDM2A|CXXC8|FBL11|FBL7|FBXL11|JHDM1A|KIAA1004
Gene ID
22992
UniProt
Q9Y2K7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Lysine (K) -specific demethylase 2A
Target
KDM2A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Epigenetics, Cancer, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
80-132 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
369-649aa

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