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KCNK18 antibody

CAT: 0710-FNab04494Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04494Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Outward rectifying potassium channel. Produces rapidly activating outward rectifier K (+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G (q) -protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity) .
Synonyms
Potassium channel subfamily K member 18|TWIK-related individual potassium channel|TWIK-related spinal cord potassium channel|KCNK18|TRESK|TRIK
Gene ID
338567
UniProt
Q7Z418
Host
Rabbit
Reactivity
Human
Immunogen
Potassium channel, subfamily K, member 18
Target
KCNK18
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Cardiovascular
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
44 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

UniProtKB · Q7Z418

Potassium channel subfamily K member 18

KCNKI_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q7Z418
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
KCNK18
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5SQQ8
Protein keywords

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

Ion channelPotassium channel

Biological process

Ion transportPotassium transportTransport

Ligand

Metal-bindingPotassium

Technical term

Reference proteome

Domain

TransmembraneTransmembrane helix

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