KCNAB1 antibody

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368, PubMed:17540341, PubMed:19713757) . Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity) . Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity) . Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623) . Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757) . Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623) . Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368) . Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity) . Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764) . Enhances KCNB1 and KCNB2 channel activity (By similarity) . Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341) . Has NADPH-dependent aldoketoreductase activity (By similarity) . Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity) .

Voltage-gated potassium channel subunit beta-1|K (+) channel subunit beta-1|Kv-beta-1|KCNAB1|KCNA1B

7881

Q14722

Human, Mouse, Rat

Potassium voltage-gated channel, shaker-related subfamily, beta member 1

KCNAB1

ELISA, WB, IHC, IF

Metabolism

Immunogen affinity purified

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

≥95% as determined by SDS-PAGE

Liquid

68 kDa

4°C with ice bag

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)