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IWS1 antibody

CAT: 0710-FNab04429Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04429Size:100 µg
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Background
Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A) . The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
Synonyms
Protein IWS1 homolog|IWS1-like protein|IWS1|IWS1L
Gene ID
55677
UniProt
Q96ST2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
IWS1 homolog
Target
IWS1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
116-120 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP

UniProtKB · Q96ST2

Protein IWS1 homolog

IWS1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96ST2
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IWS1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q2TB65, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Biological process

mRNA processingmRNA splicingmRNA transportTranscriptionTranscription regulationTransport

Cellular component

Nucleus

Domain

Repeat

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