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ITPK1 antibody

CAT: 0710-FNab04421Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04421Size:100 µg
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Background
Kinase that can phosphorylate various inositol polyphosphate such as Ins (3,4,5,6) P4 or Ins (1,3,4) P3. Phosphorylates Ins (3,4,5,6) P4 at position 1 to form Ins (1,3,4,5,6) P5. This reaction is thought to have regulatory importance, since Ins (3,4,5,6) P4 is an inhibitor of plasma membrane Ca (2+) -activated Cl (-) channels, while Ins (1,3,4,5,6) P5 is not. Also phosphorylates Ins (1,3,4) P3 on O-5 and O-6 to form Ins (1,3,4,6) P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins (1,3,4,5) P4 and Ins (1,3,4,6) P4 to Ins (1,3,4) P3, and Ins (1,3,4,5,6) P5 to Ins (3,4,5,6) P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins (1,3,4,5) P4 and Ins (1,3,4,6) P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.
Synonyms
Inositol-tetrakisphosphate 1-kinase|Inositol 1,3,4-trisphosphate 5/6-kinase (Inositol-triphosphate 5/6-kinase, Ins (1,3,4) P (3) 5/6-kinase) |ITPK1
Gene ID
3705
UniProt
Q13572
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Inositol 1,3,4-triphosphate 5/6 kinase
Target
ITPK1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
45 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

UniProtKB · Q13572

Inositol-tetrakisphosphate 1-kinase

ITPK1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13572
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITPK1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.1.134
Processing
—
Secondary accessions
Q9BTL6, Q9H2E7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Molecular function

HydrolaseIsomeraseKinaseTransferase

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