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IPO4 antibody

CAT: 0710-FNab04375Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04375Size:100 µg
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Background
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity) . Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Synonyms
Importin-4 (Imp4) |Importin-4b (Imp4b) |Ran-binding protein 4 (RanBP4) |IPO4|IMP4B|RANBP4
Gene ID
79711
UniProt
Q8TEX9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Importin 4
Target
IPO4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, IP
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
118 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF, IP

UniProtKB · Q8TEX9

Importin-4

IPO4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8TEX9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IPO4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Imp4
EC number
—
Processing
—
Secondary accessions
B2RN95, Q2NL96, Q86TZ9, Q8NCG8, Q96SJ3, Q9BTI4, Q9H5L0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Acetylation

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Biological process

Protein transportTransport

Domain

Repeat

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