INTS3 antibody

CAT: 0710-FNab04361Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab04361Size:100 µg
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Background
Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.
Synonyms
Integrator complex subunit 3 (Int3) |SOSS complex subunit A|Sensor of single-strand DNA complex subunit A (SOSS-A, Sensor of ssDNA subunit A) |INTS3|C1orf193|C1orf60
Gene ID
65123
UniProt
Q68E01
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Integrator complex subunit 3
Target
INTS3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
118 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP

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