INTS3 antibody

Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.

Integrator complex subunit 3 (Int3) |SOSS complex subunit A|Sensor of single-strand DNA complex subunit A (SOSS-A, Sensor of ssDNA subunit A) |INTS3|C1orf193|C1orf60

65123

Q68E01

Human, Mouse, Rat

Integrator complex subunit 3

INTS3

ELISA, WB, IP

Metabolism

Immunogen affinity purified

WB: 1:500-1:2000; IP: 1:200-1:2000

≥95% as determined by SDS-PAGE

Liquid

118 kDa

4°C with ice bag

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)