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ITGA5 antibody

CAT: 0710-FNab04347Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04347Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877) . ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881) .
Synonyms
Integrin alpha-5|CD49 antigen-like family member E|Fibronectin receptor subunit alpha|Integrin alpha-F|VLA-5|Integrin alpha-5 heavy chain|Integrin alpha-5 light chain|ITGA5|FNRA
UniProt
P08648
Host
Rabbit
Reactivity
Human, Rat, Mouse, Monkey
Immunogen
Integrin, alpha 5
Target
ITGA5
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Stem Cells, Immunology, Cardiovascular, Cancer
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
120 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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