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INSIG1 antibody

CAT: 0710-FNab04333Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04333Size:100 µg
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Background
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs) . Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.
Synonyms
Insulin-induced gene 1 protein (INSIG-1) |INSIG1
Gene ID
3638
UniProt
O15503
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Insulin induced gene 1
Target
INSIG1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
28-31;66-70 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · O15503

Insulin-induced gene 1 protein

INSI1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15503
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
INSIG1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
INSIG-1
EC number
—
Processing
—
Secondary accessions
A4D2N1, A8K6L0, Q53XW8, Q9BUV5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cholesterol metabolismLipid metabolismSteroid metabolismSterol metabolism

Cellular component

Endoplasmic reticulumMembrane

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Ligand

Lipid-binding

Domain

TransmembraneTransmembrane helix

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