INPP5D antibody

• Background:

  Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns (3,4,5) P3) to produce PtdIns (3,4) P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns (1,3,4,5) P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.

• Synonyms:

  Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1|Inositol polyphosphate-5-phosphatase D|Inositol polyphosphate-5-phosphatase of 145 kDa (SIP-145) |Phosphatidylinositol 4,5-bisphosphate 5-phosphatase|SH2 domain-containing inositol 5'-phosphatase 1 (SH2 domain-containing inositol phosphatase 1, SHIP-1) |p150Ship (hp51CN) |INPP5D|SHIP|SHIP1

• Gene ID:

  3635

• UniProt:

  Q92835

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Inositol polyphosphate-5-phosphatase, 145kDa

• Target:

  INPP5D

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IF

• Field of Research:

  Immunology, Signal Transduction, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500 - 1:2000; IF: 1:20 - 1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  145 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IF