IMPA1 antibody

CAT: 0710-FNab04300Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0710-FNab04300Size:100 µg

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Background

This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1, 4, 5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1, 3-diphosphate, myo-inositol-1, 4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti- manic and anti- depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

Synonyms

Gene ID

3612

UniProt

P29218

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Inositol (myo) -1 (or 4) -monophosphatase 1

Target

IMPA1

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB, IHC, IF

Field of Research

Signal Transduction, Metabolism

Purification

Immunogen affinity purified

Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

30 kDa

Shipping Conditions

4°C with ice bag

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, WB, IHC, IF

UniProtKB · P29218

Inositol monophosphatase 1

IMPA1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P29218
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: IMPA1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: IMP 1, IMPase 1
EC number: 3.1.3.25
Processing: —
Secondary accessions: B2R733, B4DLN3, B7Z6Q4, J3KQT7, Q9UK71

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cytoplasm

Molecular function

Hydrolase

Disease

Intellectual disability

Ligand

LithiumMagnesiumMetal-binding

PTM

Phosphoprotein

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Alternative Products

Catalog	Name
C44247-01	IMPA1 Antibody