IL33 antibody

CAT: 0710-FNab04272Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab04272Size:100 µg
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Background
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016) . Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528) . In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074) . This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100) .
Synonyms
Interleukin-33 (IL-33) |Interleukin-1 family member 11 (IL-1F11) |Nuclear factor from high endothelial venules (NF-HEV) |Interleukin-33 (95-270) |Interleukin-33 (99-270) |Interleukin-33 (109-270) |IL33|C9orf26|IL1F11|NFHEV
Gene ID
90865
UniProt
O95760
Host
Mouse
Reactivity
Human
Immunogen
Interleukin 33
Target
IL33
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, IHC, WB
Field of Research
Immunology, Cardiovascular
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
35 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
4E8
Tested Applications
ELISA, IHC, WB
Immunogen Sequence
1-270aa

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