IL23A antibody

• Background:

  Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

• Synonyms:

  Interleukin-23 subunit alpha (IL-23 subunit alpha, IL-23-A) |Interleukin-23 subunit p19 (IL-23p19) |IL23A|SGRF

• Gene ID:

  51561

• UniProt:

  Q9NPF7

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Interleukin 23, alpha subunit p19

• Target:

  IL23A

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Immunology, Signal Transduction, Developmental biology

• Purification:

  Protein A+G purification

• Dilution:

  WB: 1:500-1:2000; IHC: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  21 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID:

  2G1

• Tested Applications:

  ELISA, WB, IHC

• Immunogen Sequence:

  20-189aa