IL17A antibody

• Background:

  IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO) . High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.

• Synonyms:

  Interleukin-17A (IL-17, IL-17A) |Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8) |IL17A|CTLA8|IL17

• Gene ID:

  3605

• UniProt:

  Q16552

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Interleukin 17A

• Target:

  IL17A

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Applications:

  ELISA, WB, FC

• Field of Research:

  Immunology, Cardiovascular, Signal Transduction

• Purification:

  Protein A+G purification

• Dilution:

  WB: 1:500-1:1000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  18 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID:

  5E2

• Tested Applications:

  ELISA, WB, FC

• Immunogen Sequence:

  1-155aa