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IGHM antibody

CAT: 0710-FNab04185Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04185Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts.
Synonyms
Immunoglobulin heavy constant mu|Ig mu chain C region|Ig mu chain C region BOT|Ig mu chain C region GAL|Ig mu chain C region OU|IGHM
UniProt
P01871
Host
Rabbit
Reactivity
Human
Immunogen
Immunoglobulin heavy constant mu
Target
IGHM
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Immunology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
75 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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