IFT57 antibody

• Background :

  Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity) . Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.

• Synonyms :

  Intraflagellar transport protein 57 homolog|Dermal papilla-derived protein 8|Estrogen-related receptor beta-like protein 1|HIP1-interacting protein|MHS4R2|IFT57|DERP8|ESRRBL1|HIPPI

• Gene ID :

  55081

• UniProt :

  Q9NWB7

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Intraflagellar transport 57 homolog (Chlamydomonas)

• Target :

  IFT57

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IHC, IP

• Field of Research :

  Neuroscience, Metabolism

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  49 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IHC, IP