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HMGCL antibody

CAT: 0710-FNab03928Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab03928Size:100 µg
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Background
The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms
Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL, HMG-CoA lyase) |3-hydroxy-3-methylglutarate-CoA lyase|HMGCL
Gene ID
3155
UniProt
P35914
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
Target
HMGCL
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
30 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · P35914

Hydroxymethylglutaryl-CoA lyase, mitochondrial

HMGCL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35914
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HMGCL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
HL, HMG-CoA lyase
EC number
4.1.3.4
Processing
Precursor
Secondary accessions
B4DUP4, B7UCC6, D3Y5K7, Q6IBC0, Q96FP8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationDisulfide bond

Coding sequence diversity

Alternative splicing

Disease

Disease variant

Biological process

Lipid metabolism

Molecular function

Lyase

Ligand

Metal-binding

Cellular component

MitochondrionPeroxisome

Domain

Transit peptide

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