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HIF1A antibody

CAT: 0710-FNab03859Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab03859Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
Synonyms
Hypoxia-inducible factor 1-alpha (HIF-1-alpha, HIF1-alpha) |ARNT-interacting protein|Basic-helix-loop-helix-PAS protein MOP1|Class E basic helix-loop-helix protein 78 (bHLHe78) |Member of PAS protein 1|PAS domain-containing protein 8|HIF1A|BHLHE78|MOP1|PASD8
Gene ID
3091
UniProt
Q16665
Host
Rabbit
Reactivity
Human
Immunogen
Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Target
HIF1A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, IF, FC, WB
Field of Research
Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Neuroscience, Stem Cells
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000; IHC: 1:50-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
120 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, IF, FC, WB

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