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HEY1 antibody

CAT: 0710-FNab03849Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab03849Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750) . Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867) . Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737) .
Synonyms
Hairy/enhancer-of-split related with YRPW motif protein 1|Cardiovascular helix-loop-helix factor 2 (CHF-2) |Class B basic helix-loop-helix protein 31 (bHLHb31) |HES-related repressor protein 1|Hairy and enhancer of split-related protein 1 (HESR-1) |Hairy-related transcription factor 1 (HRT-1, hHRT1) |HEY1|BHLHB31|CHF2|HERP2|HESR1|HRT1
Gene ID
23462
UniProt
Q9Y5J3
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Hairy/enhancer-of-split related with YRPW motif 1
Target
HEY1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Cardiovascular, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
33 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

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